Faculty Research

Abstract Imaging-based spatial transcriptomics technologies such as MERFISH offer snapshots of cellular processes in unprecedented detail, but new analytic tools are needed to realize their full...

The Han Lab develops and applies state-of-the-art imaging-based spatial omics technologies to study how the brain encodes information. Spatial omics characterizes the molecular profile of the brain...

Abstract The prevalence of orthopedic implants is increasing with an aging population. These patients are vulnerable to risks from periprosthetic infections and instrument failures. Here, we present...

Abstract Three adult littermates were diagnosed with Brucella canis, two of which were diagnosed with discospondylitis. The first littermate, a 2-year-old spayed-female Labrador Retriever,...

Abstract The bearded dragon (Pogona vitticeps) has become a popular companion lizard, and as such, clients have increasingly come to expect the application of advanced diagnostic and...

Abstract Current treatment options for feline epilepsy are limited to medications that require administration of multiple doses per day or administration of a capsule or large tablet. Expanding the...

Abstract The cellular basis of age-related impairments of hippocampal function is not fully understood. In order to evaluate the role of somatostatin-positive (Sst+) interneurons in the dentate...

Abstract Research indicates that eye movements can reveal expressions of memory for previously studied relationships. Specifically, eye movements are disproportionately drawn to test items that were...

Abstract Contextual information plays a critical role in directed forgetting (DF) of lists of items, whereas DF of individual items has been primarily associated with item-level processing. This...

Abstract Psychological and neuroscientific experiments have established that people can intentionally forget information via different strategies: direct suppression and thought substitution....

Abstract Humans have the ability to intentionally forget information via different strategies, included suppression of encoding (directed forgetting) and mental replacement of the item to encode (...

Abstract Current developmental psychopathology models indicate that schizophrenia can be understood as the most extreme expression of a multidimensional continuum of symptoms and impairment referred...

Abstract Cryptococcus-associated immune reconstitution inflammatory syndrome (C-IRIS) is a condition frequently occurring in immunocompromised patients receiving antiretroviral therapy. C-...

Abstract Inflammation during prenatal development can be detrimental to neurodevelopmental processes, increasing the risk of neuropsychiatric disorders. Prenatal exposure to maternal viral infection...

Our research is anchored within the fields of immunology, microbiology, and developmental and behavioral neuroscience. Using translational animal models, we investigate the inflammatory pathways...

Abstract Membrane lipids control the cellular activity of kinases containing the Src homology 2 (SH2) domain through direct lipid-SH2 domain interactions. Here we report development of new...

Abstract The aromatic side-chains of phenylalanine, tyrosine, and tryptophan interact with their environments via both hydrophobic and electrostatic interactions. Determining the extent to which...

Abstract Phospholipid extrusion by ABC subfamily A (ABCA) exporters is central to cellular physiology, although the specifics of the underlying substrate interactions and transport mechanisms remain...

Abstract The initial step in the sensory transduction pathway underpinning hearing and balance in mammals involves the conversion of force into the gating of a mechanosensory transduction channel1....

Abstract Prestin is a high-density motor protein in the outer hair cells (OHCs), whose conformational response to acoustic signals alters the shape of the cell, thereby playing a major role in sound...

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike glycoprotein is the prime target for vaccines, diagnostics, and therapeutic antibodies against the virus. While anchored...

Abstract Spinster (Spns) lipid transporters are critical for transporting sphingosine-1-phosphate (S1P) across cellular membranes. In humans, Spns2 functions as the main S1P transporter in...

Abstract ABCG2 is an ATP-binding cassette (ABC) transporter that extrudes a wide range of xenobiotics and drugs from the cell and contributes to multidrug resistance in cancer cells. Following our...

Abstract Gram-negative bacteria pose a serious public health concern due to resistance to many antibiotics, caused by the low permeability of their outer membrane (OM). Effective antibiotics use...

Why ultrasound? Ultrasound is a valuable and unique modality that can be used to both image and treat patients in the clinic. It is safe, cost-effective, free of ionizing radiation, and widely...

As evolutionary neurobiologists, our work directly counters human-centric narratives of cognition and behavior (i.e. we show that humans are not the only organisms with interesting and complex mental...

Abstract Ligand-independent activation of receptor tyrosine kinases (RTKs) allows for dissecting out the receptor-specific signaling outcomes from the pleiotropic effects of the ligands. In this...

Abstract Neuroregeneration is a dynamic process synergizing the functional outcomes of multiple signaling circuits. Channelrhodopsin-based optogenetics shows the feasibility of stimulating neural...

Abstract Optogenetics uses light-inducible protein-protein interactions to precisely control the timing, localization, and intensity of signaling activity. The precise spatial and temporal...

Abstract Mitochondria are highly dynamic organelles whose fragmentation by fission is critical to their functional integrity and cellular homeostasis. Here, we develop a method via optogenetic...

Abstract Background: Opsin-based optogenetics has emerged as a powerful biomedical tool using light to control protein conformation. Such capacity has been initially demonstrated to...

Abstract Understanding the regulatory architecture of phenotypic variation is a fundamental goal in biology, but connections between gene regulatory network (GRN) activity and individual differences...

Abstract Understanding how genotypic variation results in phenotypic variation is especially difficult for collective behaviour because group phenotypes arise from complex interactions among group...

Abstract Adverse social experience affects social structure by modifying the behavior of individuals, but the relationship between an individual's behavioral state and its response to adversity is...

Abstract Objectives: Masked speech recognition is typically assessed as though the target and background talkers are all directly facing the listener. However, background speech in...

Abstract The use of spectrally degraded speech signals deprives listeners of acoustic information that is useful for speech perception. Several popular speech corpora, recorded decades ago, have...

Abstract Recent work has demonstrated that high-frequency (>6 kHz) and extended high-frequency (EHF; >8 kHz) hearing is valuable for speech-in-noise recognition. Several studies also indicate...

Abstract Proper neural function depends on the correct specification of individual neural fates, controlled by combinations of neuronal transcription factors. Different neural types are sequentially...

Abstract During development, neural progenitors undergo temporal patterning as they age to sequentially generate differently fated progeny. Temporal patterning of neural progenitors is relatively...

Abstract During development, neural progenitors are temporally patterned to sequentially generate a variety of neural types. In Drosophila neural progenitors called neuroblasts, temporal...

Abstract Temporal patterning is an important mechanism for generating a great diversity of neuron subtypes from a seemingly homogenous progenitor pool in both vertebrates and invertebrates. ...

Abstract How axon guidance pathways are utilized in coordination with temporal and spatial patterning of neural progenitors to regulate neuropil assembly is not well understood. We study this...

Abstract Notch-dependent binary fate choice between sister neurons is one of the mechanisms to generate neural diversity. How these upstream neural fate specification programs regulate downstream...

Abstract Estrogen is a disease-modifying factor in multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE) via estrogen receptor alpha (ERα). However, the...

Abstract The increase in social acceptance and legalization of cannabis over the last several years is likely to increase the prevalence of its co-use with alcohol. In spite of this, the potential...

Abstract Natural selection acts on underlying mechanisms to fine-tune expression of behaviour across scales – within individuals, among individuals, between sexes and across species...

Abstract The emergence of complex social interactions is predicted to be an important selective force in the diversification of communication systems. Parental care presents a key social context in...

Abstract The electrical activity of neurons has a spatiotemporal footprint that spans three orders of magnitude. Traditional electrophysiology lacks the spatial throughput to image the activity of...

Abstract A recent theranostic approach to address Alzheimer's disease (AD) utilizes multifunctional targets that both tag and negate the toxicity of AD biomarkers. These compounds, which emit...

Abstract Non-ergodicity of neuronal dynamics from rapid ion channel gating through the membrane induces membrane displacement statistics that deviate from Brownian motion. The membrane dynamics from...

Abstract Noncanonical genomic imprinting can cause biased expression of one parental allele in a tissue; however, the functional relevance of such biases is unclear. To investigate ethological roles...

Abstract Practice in real-world settings exhibits many idiosyncracies of scheduling and duration that can only be roughly approximated by laboratory research. Here we investigate 39,157 individuals...

Abstract When responding to queries for information, people control the grain size (precision–coarseness) of the information they communicate based on competing goals of accuracy and...

Abstract Background: A core cognitive attribute of depression is lower specificity in the expression of autobiographical memories. Despite interventions targeting memory specificity...

Abstract Signal detection theory (SDT; Tanner & Swets in Psychological Review 61:401-409, 1954) is a dominant modeling framework used for evaluating the accuracy of diagnostic systems that seek...

Abstract Written memoranda of conversations, or memcons, provide a near-contemporaneous record of what was said in conversation, and offer important insights into the activities of high-profile...

Abstract The mechanisms underlying a tendency among individuals with depression to report personal episodic memories with low specificity remain to be understood. We assessed a sample of...

Abstract After a crime is committed, investigators may query witnesses about whether they believe they will be to identify the perpetrator. However, we know little about how such metacognitive...

Abstract Prior familiarity with a face seems to substantively change the way we encode and recognize later instances of that face. We report five experiments that examine the effects of varying...

Abstract Remarkable progress in bioengineering over the past two decades has enabled the formulation of fundamental design principles for a variety of medical and non-medical applications. These...

Abstract Bioengineering approaches that combine living cellular components with three-dimensional scaffolds to generate motion can be used to develop a new generation of miniature robots....

Abstract Fragile X (FX) syndrome is one of the leading inherited causes of autism spectrum disorder (ASD). A majority of FX and ASD patients exhibit sensory hypersensitivity, including auditory...

Abstract Listening in noisy or complex sound environments is difficult for individuals with normal hearing and can be a debilitating impairment for those with hearing loss. Extracting meaningful...

Abstract Fragile X Syndrome (FXS) is a leading inherited cause of autism and intellectual disability, resulting from a mutation in the FMR1 gene and subsequent loss of its...

Abstract From a biobehavioral framework, mother–child physiological and behavioral coordination are interdependent processes that contribute to children's socioemotional development. Little is known...

Abstract Early attachment shapes brain development underlying emotion regulation. Given that sensitivity to affective cues is heightened during adolescence and effective emotion regulation...

Abstract Our primary objective was to examine the extent to which moment-to-moment associations between preschool-aged children's behavior and maternal emotional support differed for mothers showing...

Abstract The COVID-19 pandemic has necessitated innovations in data collection protocols, including use of virtual or remote visits. Although developmental scientists used virtual...

Abstract This longitudinal study examined the prospective association between toddler–mother attachment to adolescents’ (n = 52; 34 boys; Mage = 13.22 years; 90% White) behavioral...

Abstract Early functioning of neural networks likely underlies the flexible switching between internal and external orientation and may be key to the infant’s ability to effectively engage in social...

Abstract Frogs call in acoustically dense choruses to attract conspecific females. Their calls can potentially reveal their location to predators, many of which are mammals. However, frogs and...

Abstract Negative correlations in the sequential evolution of interspike intervals (ISIs) are a signature of memory in neuronal spike-trains. They provide coding benefits including firing-rate...

Information about the Johnson Lab.

Information about the Cellular Neuroscience Imaging Laboratory.

Information about the Rodriguez-Zas's Laboratory of Statistical Genetics and Bioinformatics.

Information about IKIDS.

Information about the Grosman Lab.

Information about the Huesmann Lab.

Information about the Li Lab.

Information about the Liang Lab.

Information about the Gulley Lab.

Information about the Shen Lab.

Information about the Context, Memory, and Forgetting Lab.

Information about the Theoretical and Computational Biophysics Group.

Information about the Zhang Lab.

Learn about the Information and Intelligence Group.

Information about the Computational Structural Biology and Molecular Biophysics Group.

Information about the Tsai Lab.

Information about the Lam Lab.

Information about the MRFIL.

Information about the Stubbs Lab.

Learn more about Integrated Neuro Technologies.  

Information about the Steelman Lab.

Information about the Hinman Lab.

Information about the Schroeder Lab.

Information about the Sweedler Research Group.

Information about the Saif Lab.

Information about the Rudolph Lab.

Information about the Robinson Lab.

Information about the Koyejo Group.

Information about the Raetzman Lab.

Information about the Exercise Psychophysiology Laboratory.

Learn more about the Nelson Lab.

Learn more about the AANCL.

Information about the Rhodes Laboratory.

Information about the ANEx Lab.

Information about the Mehta Research Group.

Information about the Mahoney Lab.

Information about the Human Speech Recognition Group.

Information about the Neuroscience of Dance in Health and Disability Laboratory.

Information about the Llano Lab.

Information about the Leckband Research Group.

Information about the Kukekova Lab.

Information about the Octopus Project.

Information about The Laboratory of Hybrid Materials for the Bioengineering of Interface and Biotransport.

Information about The Thin Film & Charged Particle Research Laboratory.

Information about the Ko Laboratory.

Information about the Douglas L Jones Group.

Information about the BCNN Lab.

Information about the Juraska Lab.

Information about the Inoue Laboratory.

Information about the Brain and Cognitive Development Lab.

Information about the Auditory Cognitive Neuroscience Lab.

Information about the Human Dynamics and Controls Lab.

Information about the MFPRL.

Information about the CANOPY Lab.

Information about the Cowbird Lab.

Information about the Dolcos Lab, or SCOPE.

Information about the Slug Lab.

Information about the CAB Lab.

Learn more about the Cognitive Neuroimaging Laboratory.

Information about the Fuller Lab.

Information about the Nutrition, Health, and Neuroscience Laboratory.

Information about the Das Lab.

Want to learn more about the Connect Lab? Click here!

Information about the Biophotonics Imaging Laboratory.

Information about the Memory Systems Lab

Information about the Chung Lab.

Information about the Christian Lab.

Information about the Cemen Lab

Information about the Bretl Research Group.

Information about the Human Memory and Cognition Lab

Information about the Bell Lab.

Learn about the Attention and Perception Lab.

Information about LIBNA.

Information about the Chan Lab.

Information about the Clockworks Lab.

Research summaries of all active Neuroscience laboratories with our faculty.