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Grace Lyu

Profile picture for Grace Lyu

Contact Information

Veterinary Medicine Basic Sciences Building
2001 S Lincoln Ave, Urbana, IL 61802
Advisor - Dr. Uwe Rudolph

Research Interests

Education

B.S. in Neuroscience

University of California San Diego,  2019

Courses Taught

PSYC 100 - Intro Psych. FALL 2023.

Highlighted Publications

Welch, A.C., Zhang, J., Lyu, J. et al. Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice. Mol Psychiatry 26, 3765–3777 (2021). https://doi.org/10.1038/s41380-019-0633-8.

Lyu J, Nagarajan R, Kambali M, Wang M, Rudolph U. Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction. PNAS Nexus, Volume 2, Issue 5, May 2023, pgad134, https://doi.org/10.1093/pnasnexus/pgad134.

Nagarajan R, Lyu J, Kambali M, et al. Genetic Ablation of Dentate Hilar Somatostatin-Positive GABAergic Interneurons is Sufficient to Induce Cognitive Impairment. Mol Neurobiol. 2024 Feb;61(2):567-580. doi: 10.1007/s12035-023-03586-3.

Kambali M, Li Y, Unichenko P, Feria Pliego JA, et al. An increased copy number of glycine decarboxylase (GLDC) associated with psychosis reduces extracellular glycine and impairs NMDA receptor function. Mol Psychiatry. 2024 Aug 30. doi: 10.1038/s41380-024-02711-5.

Nagarajan R, Lyu J, Kambali M, et al. Chronic intermittent propofol attenuates surgery-induced neuroinflammation, apoptosis, and cognitive impairment in aged mice. bioRxiv; 2022. DOI: 10.1101/2022.10.26.513964.

Nagarajan, R., Lyu, J., Kambali, M., Wang, M., Pearce, R.A. and Rudolph, U. (2022), Reduction of Postoperative Cognitive Deficits in Aged Mice by Chronic Intermittent Propofol. The FASEB Journal, 36:. https://doi.org/10.1096/fasebj.2022.36.S1.R4256.