Additional Campus Affiliations
Phil and Ann Sharp Scholar, Biochemistry
Professor, Biochemistry
Affiliate, Chemistry
Affiliate, Carl R. Woese Institute for Genomic Biology
Recent Publications
Yeh, I. J., Ghozayel, M. K., Bum-Erdene, K., & Meroueh, S. O. (2026). Degradation of the TEAD·YAP/TAZ Transcription Factor Complex by Heterobifunctional Small Molecules That Bind to the TEAD Allosteric Lipid Pocket. ACS chemical biology, 21(5), 1199-1210. https://doi.org/10.1021/acschembio.6c00170
Landgraf, A. D., Brenner, R., Ghozayel, M. K., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2025). Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation. ChemMedChem, 20(12), Article e202400624. https://doi.org/10.1002/cmdc.202400624
Yeh, I. J., Bum-Erdene, K., Ghozayel, M. K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2025). Small-Molecule Covalent Stabilization and Inhibition of the TEAD·YAP1 Transcription Factor in Cancer Cells. ACS chemical biology, 20(9), 2142-2158. https://doi.org/10.1021/acschembio.5c00283
Brenner, R. J., Landgraf, A. D., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62(22), 3206-3213. https://doi.org/10.1021/acs.biochem.3c00378
Bum-Erdene, K., Ghozayel, M. K., Zhang, M. J., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction. RSC Medicinal Chemistry, 14(9), 1803-1816. https://doi.org/10.1039/d3md00264k