Professor

Additional Campus Affiliations

Phil and Ann Sharp Scholar, Biochemistry
Professor, Biochemistry
Affiliate, Chemistry
Affiliate, Carl R. Woese Institute for Genomic Biology

Recent Publications

Landgraf, A. D., Brenner, R., Ghozayel, M. K., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2025). Small-Molecule KRAS Inhibitors by Tyrosine Covalent Bond Formation. ChemMedChem, 20(12), Article e202400624. https://doi.org/10.1002/cmdc.202400624

Brenner, R. J., Landgraf, A. D., Bum-Erdene, K., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62(22), 3206-3213. https://doi.org/10.1021/acs.biochem.3c00378

Bum-Erdene, K., Ghozayel, M. K., Zhang, M. J., Gonzalez-Gutierrez, G., & Meroueh, S. O. (2023). Chloroacetamide fragment library screening identifies new scaffolds for covalent inhibition of the TEAD·YAP1 interaction. RSC Medicinal Chemistry, 14(9), 1803-1816. https://doi.org/10.1039/d3md00264k

Bum-Erdene, K., Yeh, I. J., Gonzalez-Gutierrez, G., Ghozayel, M. K., Pollok, K., & Meroueh, S. O. (2023). Small-Molecule Cyanamide Pan-TEAD·YAP1 Covalent Antagonists. Journal of Medicinal Chemistry, 66(1), 266-284. https://doi.org/10.1021/acs.jmedchem.2c01189

Hussain, M. S., Liu, D., Alilain, W. J., & Meroueh, S. O. (2023). Covalent Fragment Inhibits RhoA Activation by Guanine Exchange Factors. ACS Chemical Neuroscience, 14(14), 2509-2516. https://doi.org/10.1021/acschemneuro.3c00154

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