Georgiy Yudintsev

Research Interests

Auditory neuroscience, sensory systems, neuroanatomy, and attention.

Research Description

Our brains are constantly presented with the problem of extracting meaningful information from the surroundings, and in fact, our optimal behavior and survival depend on this function of the brain. My research focuses on understanding the anatomy and physiology of higher centers in the brain, such as the cerebral cortex, which help animals extract sound information from the environment. To illustrate how complex this task can be, imagine being at a loud party where multiple people are talking and music is playing. Yet, most people are able to focus on one conversation even when many conversations are taking place at the same time. I am trying to understand the organization and functions of the neurons that help us accomplish similar tasks. Even more specifically, my research focuses on describing structural and functional heterogeneity between groups of corticofugal neurons that project to the inferior colliculus - a midbrain integration center for sound information. Our research findings are suggestive of the existence of at least two classes of corticocollicular neurons, one of which is most likely involved in fast modulation of responses to sound, while the second class may provide more long-lasting influences on sound processing that arise from memory and emotion systems in the brain.

Education

B.S. in Molecular and Cellular Biology Honors, University of Illinois at Urbana-Champaign

Awards and Honors

2018                    UIUC List of Teachers Marked As Excellent By Their Students.

2017                    Bob Bilger Graduate Student Award.

2016                    UIUC List of Teachers Marked As Excellent By Their Students.

2013                    Honors and Departmental Distinction in Molecular and Cellular Biology.

2012                    Mayo Clinic Summer Undergraduate Research Fellowship.

Courses Taught

MCB 314 Introduction to Neurobiology

MCB 244 Human Anatomy and Physiology I

MCB 247 Human Anatomy and Physiology Lab II

MCB 150 Molecular and Cellular Basis of Life

BBHD Brain, Behavior and Human Development (UIC College of Medicine)

Publications:

Patel, Mili B., Stacy Sons, Georgiy Yudintsev, Alexandria MH Lesicko, Luye Yang, Gehad A. Taha, Scott M. Pierce, and Daniel A. Llano. (2016) “Anatomical characterization of subcortical descending projections to the inferior colliculus in mouse." Journal of Comparative Neurology.

Podratz, J. L., H. Lee, P. Knorr, S. Koehler, S. Forsythe, K. Lambrecht, S. Arias, K. Schmidt, G. Steinhoff, G. Yudintsev, A. Yang, E. Trushina and A. Windebank (2016). "Cisplatin induces mitochondrial deficits in Drosophila larval segmental nerve." Neurobiology of Disease.

BJ. Slater, S. Sons, G. Yudintsev, D. Llano. "Thalamocortical and intracortical inputs differentiate layer-specific mouse auditory corticocollicular neurons." (Journal of Neuroscience, accepted 2018).

D. Llano, C. Ma, U. Di Fabrizio, K. Stebbings, G. Yudintsev, R Kenyon and T Berger-Wolf. “A novel dynamic network imaging analysis method reveals aging-related fragmentation of cortical networks in mouse.” (In preparation).

Yudintsev, G. and Llano, D.A. “Connectional heterogeneity in the mouse auditory corticocollicular system.” (In preparation).

Book chapters:

Yudintsev G., Lee C.M., Asilador A. and Llano D.A. (2017) “Guide to transcranial in vivo imaging of sound-evoked activity in the auditory cortex of GCaMP6s mice” In Neuromethods: Basic Neurobiology Techniques. Wright N. ed. Springer Publishers. (Invited, submitted).

Conference proceedings:

Patel, Mili B., Luye Yang, Gehad A. Taha, Daniel A. Llano, Alexandria MH Lesicko, and Georgiy Yudintsev. (2015) The thalamotectal system: An ancient projection for modulating the auditory midbrain. In Proceedings of Meetings on Acoustics, vol. 25, no. 1, p. 010004. Acoustical Society of America.