Department of Molecular and Integrative Physiology,
University of Illinois at Urbana-Champaign,
407 South Goodwin Avenue, 427 Burrill Hall,
Urbana, IL 61801
Epilepsy, Alzheimer's Disease (AD), STriatal Enriched Protein Phosphatase (STEP), Hippocampal CA2 neurons, Intrinsic excitability, Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, Hippocampal Network activity, Amyloid-beta.
Epilepsy is a chronic brain disorder characterized by recurrent epileptic seizures, which are indicative of abnormally excessive and synchronous discharges of neuronal activity. Abnormal network excitability in epilepsy could arise from reduced synaptic inhibition, enhanced excitatory synaptic strength, and/or elevated intrinsic excitability, all of which were regulated by ion channels.
Striatal enriched protein phosphatase (STEP) is a brain specific tyrosine phosphatase important for Hebbian plasticity at excitatory synapses. A membrane-bound splice variant STEP61 dephosphorylates and down-regulates its substrates including AMPA- and NMDA-type glutamate receptors. Despite extensive studies in characterizing its role in synaptic receptors and plasticity, whether STEP61 regulates voltage-dependent ion channels that determine intrinsic excitability of hippocampal neurons and if such regulation contributes to pathogenesis of epilepsy is unknown.
M.S. in Neuroscience, Seoul National University, South Korea (2009)
B.S. in Biological Science, Konkuk University, South Korea (2007)
Awards and Honors
Pre-doctoral research fellowship 2018-2019, American Epilepsy Society, USA
Pre-doctoral research award 2015, Association of Korean Neuroscientist, USA
Research fellowship, Brain Korea 21 2007-2009, Seoul National University, South Korea