An imbalance in neuronal and synaptic excitability is a common abnormality observed in patients with various psychiatric and neurological disorders, including schizophrenia and bipolar, mood disorders, epilepsy and autism spectrum disorders. Identifying and understanding the mechanisms underlying the regulation of excitability will potentially reveal novel therapeutic targets for these diseases. My laboratory utilizes various approaches including molecular and cell biology, biochemistry, electrophysiology, and mouse genetics to understand the regulation of excitability homeostasis at synaptic, neuronal, network and system levels.