Daniel McKim

Profile picture for Daniel McKim

Contact Information

211 E R Madigan Laboratory
1201 W. Gregory Dr.
Urbana Illinois 61801
217-300-6581

Research Interests

Topics:

Psychoneuroimmunology

Stress and endocrine regulation of immune cell production

Immune regulation of behavior

Immune regulation of tumors and atherosclerosis

Brain leukocytes

 

Techniques:

RNAseq (bulk and single cell), flow cytometry and FACSorting, Animal models of stress, animal behavior, chemogenetic models of endocrine activation, immunohistochemistry, cell culture, and PCR

 

Research Description

Laboratory of Neuroimmunology: Leukocyte brain interactions

The McKim lab investigates bidirectional immune and brain communication in the context of stress and disease. We’ve shown that neuroendocrine activation during psychological stress enhances the myelopoietic production of inflammatory monocytes and granulocytes that traffic to the brain. The dynamic interaction of myeloid cells with vascular brain endothelial cells and resident microglia propagate neuroinflammatory signaling that regulates mood, cognition, and behavior. Similarly, systemic inflammation associated with peripheral disease (e.g., solid tumors, cardiovascular disease, obesity, diabetes) regulates myelopoiesis, leukocyte trafficking to the brain, and behavior through some conserved mechanisms. The McKim lab aims to address important biomedical questions from a uniquely integrative, multidisciplinary approach. 

Education

2012 - BA Psychology, The William Paterson University of New Jersey

2017 - PhD Neuroscience, The Ohio State University

 

Additional Campus Affiliations

Assistant Professor, Animal Sciences
Assistant Professor, Nutritional Sciences

Recent Publications

Liu, X., Nemeth, D. P., McKim, D. B., Zhu, L., DiSabato, D. J., Berdysz, O., ... Quan, N. (2019). Cell-Type-Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities. Immunity, 50(2), 317-333.e6. https://doi.org/10.1016/j.immuni.2018.12.012

Norden, D. M., Faw, T. D., McKim, D. B., Deibert, R. J., Fisher, L. C., Sheridan, J. F., ... Basso, D. M. (2019). Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. Journal of Neurotrauma, 36(6), 937-949. https://doi.org/10.1089/neu.2018.5806

Sawicki, C. M., Kim, J. K., Weber, M. D., Faw, T. D., McKim, D. B., Madalena, K. M., ... Sheridan, J. F. (2019). Microglia promote increased pain behavior through enhanced inflammation in the spinal cord during repeated social defeat stress. Journal of Neuroscience, 39(7), 1139-1149. https://doi.org/10.1523/JNEUROSCI.2785-18.2018

Sullivan, K. A., Bever, S. R., McKim, D. B., Godbout, J. P., Sheridan, J. F., Obrietan, K., & Pyter, L. M. (2019). Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice. Brain, Behavior, and Immunity, 80, 805-817. https://doi.org/10.1016/j.bbi.2019.05.028

Weber, M. D., McKim, D. B., Niraula, A., Witcher, K. G., Yin, W., Sobol, C. G., ... Godbout, J. P. (2019). The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat. Biological Psychiatry, 85(8), 667-678. https://doi.org/10.1016/j.biopsych.2018.10.009

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