Daniel McKim

Profile picture for Daniel McKim

Contact Information

211 E R Madigan Laboratory
1201 W. Gregory Dr.
Urbana Illinois 61801

Research Interests



Stress and endocrine regulation of immune cell production

Immune regulation of behavior

Immune regulation of tumors and atherosclerosis

Brain leukocytes



RNAseq (bulk and single cell), flow cytometry and FACSorting, Animal models of stress, animal behavior, chemogenetic models of endocrine activation, immunohistochemistry, cell culture, and PCR


Research Description

Laboratory of Neuroimmunology: Leukocyte brain interactions

The McKim lab investigates bidirectional immune and brain communication in the context of stress and disease. We’ve shown that neuroendocrine activation during psychological stress enhances the myelopoietic production of inflammatory monocytes and granulocytes that traffic to the brain. The dynamic interaction of myeloid cells with vascular brain endothelial cells and resident microglia propagate neuroinflammatory signaling that regulates mood, cognition, and behavior. Similarly, systemic inflammation associated with peripheral disease (e.g., solid tumors, cardiovascular disease, obesity, diabetes) regulates myelopoiesis, leukocyte trafficking to the brain, and behavior through some conserved mechanisms. The McKim lab aims to address important biomedical questions from a uniquely integrative, multidisciplinary approach. 


2012 - BA Psychology, The William Paterson University of New Jersey

2017 - PhD Neuroscience, The Ohio State University


Additional Campus Affiliations

Assistant Professor, Animal Sciences
Assistant Professor, Nutritional Sciences

Recent Publications

Zhu, L., Liu, X., Nemeth, D. P., DiSabato, D. J., Witcher, K. G., McKim, D. B., ... Quan, N. (2019). Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling. Brain, Behavior, and Immunity, 81, 292-304. https://doi.org/10.1016/j.bbi.2019.06.026

Sullivan, K. A., Bever, S. R., McKim, D. B., Godbout, J. P., Sheridan, J. F., Obrietan, K., & Pyter, L. M. (2019). Mammary tumors compromise time-of-day differences in hypothalamic gene expression and circadian behavior and physiology in mice. Brain, Behavior, and Immunity, 80, 805-817. https://doi.org/10.1016/j.bbi.2019.05.028

Yin, W., Gallagher, N. R., Sawicki, C. M., McKim, D. B., Godbout, J. P., & Sheridan, J. F. (2019). Repeated social defeat in female mice induces anxiety-like behavior associated with enhanced myelopoiesis and increased monocyte accumulation in the brain. Brain, Behavior, and Immunity, 78, 131-142. https://doi.org/10.1016/j.bbi.2019.01.015

Weber, M. D., McKim, D. B., Niraula, A., Witcher, K. G., Yin, W., Sobol, C. G., ... Godbout, J. P. (2019). The Influence of Microglial Elimination and Repopulation on Stress Sensitization Induced by Repeated Social Defeat. Biological Psychiatry, 85(8), 667-678. https://doi.org/10.1016/j.biopsych.2018.10.009

Norden, D. M., Faw, T. D., McKim, D. B., Deibert, R. J., Fisher, L. C., Sheridan, J. F., ... Basso, D. M. (2019). Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. Journal of Neurotrauma, 36(6), 937-949. https://doi.org/10.1089/neu.2018.5806

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