Aditi Das

Profile picture for Aditi  Das

Contact Information

3836 Veterinary Medicine Basic Sciences Building

Biography

Dr. Das received her undergraduate degree in Chemistry from Indian Institute of Technology (I.I.T.) Kanpur . She received her Ph.D. in Chemistry at Princeton University. She did her postdoctoral research with Prof. Stephen Sligar at Northwestern University Nanoscale Science and Engineering Center. 

Since 2012, her laboratory works on cytochrome P450s involved in lipid metabolism and on evaluation of the anti-inflammatory action of the lipid epoxides in neuro-inflammation model and multiple sclerosis. She also works on phytocannabinoid metabolism by cytochrome P450s. Her laboratory has been funded by several grants from American Heart Association (AHA), National Institute of Health, Multiple Sclerosis Society and other private funding.

Research Interests

Discovery of novel endogenous omega-3 endocannabinoid-like molectules with anti-neuroinflammatory and anti-pain properties

Research Description

Research Area 1: Biochemical Mechanism of Epoxygenases

  • Mechanism of CYP2J2 epoxygenase enzyme involved in metabolism of omega-3 fatty acids to generate anti-inflammatory cardioprotective lipid metabolites.
  • Mechanism of cardiotoxicity of chemotherapeutic drugs that is mediated via interaction with CYP2J2 epoxygenase

Research Area 2: Endocannabinoids & Phytocannabinoids metabolism by P450s

  • Endocannabinoid metabolism by CYP epoxygenases to generate novel anti-inflammatory endocannabinoid epoxide derivatives that bind to cannabinoid receptors.
  • Phytocannabinoid metabolism by human cytochrome P450s to form oxy-cannabinoids with altered pharmacology
  • Role of Anti-inflammatory lipid metabolites in Multiple Sclerosis (collaborator: Andrew Steelman and Rodney Johnson)
  • Role of Anti-inflammatory lipid metabolites in bone cancer pain in canine Osteosarcoma (collaborator: Prof. Timothy Fan)

Education

B.Sc.  St. Stephen's College, Delhi

M.Sc.  Indian Institute of Technology (I.I.T.) Kanpur

Ph.D. Princeton University.

Post-Doc Northwestern University Nanoscale Science and Engineering Center.

Grants

American Heart Association SDG (Role: PI)

National Institute of Health (R01) (Role: PI)

National Institute of Health (R03) (Role: PI)

National Institute of Health (R21) (Role: Co-PI)

Multiple Sclerosis Society (Role: PI)

Manus Biosynthesis. (Role: PI)

Awards and Honors

2019 Mary Swartz Rose Young Investigator Award from American Society for Nutrition (ASN)

2019 Editorial board of Frontiers in Pharmacology

2018. National Multiple Sclerosis Society, High-risk Pilot Award

2018. Gordon Hammes Scholar’s Award (runner up), Invited viewpoint in Biochemistry

2018. Faculty of 1000 recommendation for Doxorubicin Paper in Biochemistry

2018. Member (AdHoc), NIH Study Section, Macromolecular Structure and Function A Study Section

2018. Editorial Board Member, Journal of Clinical Pharmacology & Toxicology

2017. Colin Wraight best paper award from the Department of Biochemistry

2016. Editorial Board Member, ChemSelect, ChemPubSoc Europe, Wiley VCH

 2015. American Heart Association (AHA), National Scientist Development Grant

2014. NIEHS funded travel award, International Winter Eicosanoid Conference

2013. Moog Lecturer at Hauptmann Woodward Center (Prestigious lecture series)

2013. American Chemical Society (ACS) Travel Award

2013. Pew Scholar’s Award Nominee (One person from the UIUC campus)

2010. ACS Biological Division Travel Award.

2007. Outstanding Researcher Award, NSF-Nanoscale Science and Engineering Center

2005. FMC CORPORATION Graduate Fellowships in Chemistry, Princeton.

Courses Taught

VM 602: Biochemistry

VM 603: GI Physiology

Additional Campus Affiliations

Department of Biochemistry

Department of Bioengineering

Division of Nutritional Sciences

Neuroscience Program

Beckman Institute for Advanced Science and Technology

Center for Biophysics and Quantitative Biology

Cancer Center at Illinois

Recent Publications

Huff, H. C., Maroutsos, D., & Das, A. (2019). Lipid composition and macromolecular crowding effects on CYP2J2-mediated drug metabolism in nanodiscs. Protein Science, 28(5), 928-940. https://doi.org/10.1002/pro.3603

Maroutsos, D., Huff, H., & Das, A. (2019). Bacterial expression of membrane-associated cytochrome P450s and their activity assay in nanodiscs. In Methods in Molecular Biology (pp. 47-72). (Methods in Molecular Biology; Vol. 1927). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-9142-6_5

Carnevale, L. N., Arango, A. S., Arnold, W. R., Tajkhorshid, E., & Das, A. (2018). Endocannabinoid Virodhamine Is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase. Biochemistry, 57(46), 6489-6499. https://doi.org/10.1021/acs.biochem.8b00691

Carnevale, L., Arango, A., Arnold, W. R., Tajkhorshid, E., & Das, A. (2018). Endocannabinoid Virodhamine is an Endogenous Inhibitor of Human Cardiovascular CYP2J2 Epoxygenase. Biochemistry. https://doi.org/10.1021/acs.biochem.8b00691

Roy, J., Watson, J. E., Hong, I. S., Fan, T. M., & Das, A. (2018). Antitumorigenic Properties of Omega-3 Endocannabinoid Epoxides. Journal of Medicinal Chemistry, 61(13), 5569-5579. https://doi.org/10.1021/acs.jmedchem.8b00243

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