Cognitive control & network connectivity
Distant brain regions are in constant communication with each other. This communication, also called functional connectivity, is foundational to all cognition. Functional connectivity is spatially organized into many large brain networks. But how this network organization is maintained and modulated in the service of flexible cognition is poorly understood. Sepideh Sadaghiani’s lab is studying connectivity and cognitive functions of large-scale brain networks. Her lab is most interested in networks involved in cognitive control functions such as alertness and attention (cognitive control networks).
One research line of the lab seeks to delineate the function of different cognitive control networks. This research investigates how cognitive control networks modulate processes in “lower-order” brain areas such as perception in sensory cortices.
Another research line focuses on the functional role of intrinsic (spontaneous) network activity. Neural activity and communication across brain networks are continuously ongoing independent of external stimuli or tasks. Sadaghiani’s research aims at understanding why this intrinsic activity and functional connectivity exists and how it affects behavior.
Sepideh Sadaghiani’s lab combines various techniques to address these questions in the human brain including functional magnetic resonance imaging (fMRI), electroencephalography (EEG), simultaneous EEG-fMRI and genetic analyses in healthy participants and neurological patients.
For current publication list and citation record please see my Google Scholar profile
Sadaghiani S, Poline JB, Kleinschmidt A, D'Esposito M (2015) Large-scale ongoing dynamics in functional connectivity predict perception. Proceedings of the National Academy of Sciences, 112(27): 8463-8
Sadaghiani S, D'Esposito M (2014) Functional characterization of the cingulo-opercular network in the maintenance of intrinsic alertness. Cerebral Cortex, in press.
Sadaghiani S, Kleinschmidt A (2013). Functional interactions between intrinsic brain activity and behaviour. NeuroImage, 80:379-86.
Fabienne P, Sadaghiani S, Leroy C, Courvoisier DS, Maroy R, Bottlaender M (2013) High density of nicotinic receptors in the cingulo-insular network. NeuroImage, 79:42-51.
Sadaghiani S, Scheeringa R, Lehongre K, Morillon B, Giraud AL, D'Esposito M, Kleinschmidt A (2012) Alpha-band phase synchrony is related to activity in the fronto-parietal adaptive control network. Journal of Neuroscience, 32(41): 14305-14310.
Ciuciu P, Varoquaux G, Abry P, Sadaghiani S, Kleinschmidt A (2012) Scale-Free and Multifractal Time Dynamics of fMRI Signals during Rest and Task. Frontiers in Physiology 3:186. doi:10.3389/fphys.2012.00186.
Coste C, Sadaghiani S, Friston K, Kleinschmidt A (2011) Ongoing Brain Activity Fluctuations Directly Account for Inter-Trail and Indirectly for Inter-Subject Variability in Stroop Task Performance. Cerebral Cortex, 21(11): 2612-9.
Sadaghiani S, Scheeringa R, Lehongre K, Morillon B, Giraud AL, Kleinschmidt A (2010) Intrinsic Connectivity Networks, Alpha Oscillations and Tonic Alertness: A simultaneous EEG/fMRI Study. Journal of Neuroscience, 30(30): 10243-50.
Sadaghiani S, Hesselmann G, Friston KJ, Kleinschmidt A (2010) The relation of ongoing brain activity, evoked neural responses, and cognition. Frontiers in Systems Neuroscience, 4:20. doi:10.3389/fnsys.2010.00020.
Sadaghiani S*, Hesselmann G*, Friston KJ, Kleinschmidt A (2010) Predictive coding or evidence accumulation? False inference and neuronal fluctuations. PLoS One 5(3): e9926. doi:10.1371/journal.pone.0009926. *The first two authors contributed equally.
Varoquaux G, Sadaghiani S, Pinel P, Kleinschmidt A, Poline JB, Thirion B (2010) A group model for stable multi-subject ICA on fMRI datasets. NeuroImage, 51(1): 288-299.
Sadaghiani S, Hesselmann G, Kleinschmidt A (2009) Distributed and antagonistic contributions of ongoing activity fluctuations to auditory stimulus detection. Journal of Neuroscience, 29(42): 13410-7.
Sadaghiani S, Maier JX, Noppeney U (2009) Natural, metaphoric and linguistic auditory direction signals have distinct influences on visual motion processing. Journal of Neuroscience, 29(20): 6490-9.
Sadaghiani S, Ugurbil K, Uludag K (2009) Neural activity-induced modulation of BOLD post-stimulus undershoot independent of the positive response. Magnetic Resonance Imaging, 27(8): 1030-8.