Robert McCusker

rmccuske@illinois.edu

250 ERML
1201 W Gregory Dr
M/C 051
Urbana, IL 61801
Office: (217) 333-5142
Fax: 217 244-5142

Mail to:
250 ERML
1201 W Gregory Dr
M/C 051
Urbana, IL 61801
Publications

Robert McCusker

Research Assistant Professor, Animal Sciences

How environmental stimuli affect health and well being

The Immunophysiology and Behavior program is designed to understand how environmental stimuli impinge upon the immune system to affect disease resistance and how cells of the immune system, and their secreted cytokine gene products, interact with disparate physiologic systems to affect growth and development, nutrition and metabolism, neural pathways that regulate behavior, and health and well-being.

Research Areas

Representative Publications

Gibbons TE, Pence BD, Petr G, Ossyra JM, Mach HC, Bhattacharya TK, Perez S, Martin SA, McCusker RH, Kelley KW, Rhodes JS, Johnson RW, Woods JA. Voluntary wheel running, but not a diet containing (-)-epigallocatechin-3-gallate and ß-alanine, improves learning, memory and hippocampal neurogenesis in aged mice. Behav Brain Res. 2014 Oct 1; 272:131-40.View in: PubMed

Chiu GS, Darmody PT, Walsh JP, Moon ML, Kwakwa KA, Bray JK, McCusker RH, Freund GG. Adenosine through the A2A adenosine receptor increases IL-1ß in the brain contributing to anxiety. Brain Behav Immun. 2014 Oct; 41:218-31.View in: PubMed

Lawson MA, Parrott JM, McCusker RH, Dantzer R, Kelley KW, O'Connor JC. Intracerebroventricular administration of lipopolysaccharide induces indoleamine-2,3-dioxygenase-dependent depression-like behaviors. J Neuroinflammation. 2013; 10:87.View in: PubMed

Lawson MA, McCusker RH, Kelley KW. Interleukin-1 beta converting enzyme is necessary for development of depression-like behavior following intracerebroventricular administration of lipopolysaccharide to mice. J Neuroinflammation. 2013; 10:54.View in: PubMed

Kelley KW, O'Connor JC, Lawson MA, Dantzer R, Rodriguez-Zas SL, McCusker RH. Aging leads to prolonged duration of inflammation-induced depression-like behavior caused by Bacillus Calmette-Guérin. Brain Behav Immun. 2013 Aug; 32:63-9.View in: PubMed

McCusker RH, Kelley KW. Immune-neural connections: how the immune system's response to infectious agents influences behavior. J Exp Biol. 2013 Jan 1; 216(Pt 1):84-98.View in: PubMed

Park SE, Lawson M, Dantzer R, Kelley KW, McCusker RH. Insulin-like growth factor-I peptides act centrally to decrease depression-like behavior of mice treated intraperitoneally with lipopolysaccharide. J Neuroinflammation. 2011; 8:179.View in: PubMed

Park SE, Dantzer R, Kelley KW, McCusker RH. Central administration of insulin-like growth factor-I decreases depressive-like behavior and brain cytokine expression in mice. J Neuroinflammation. 2011; 8:12.View in: PubMed

Palin K, Bluthé RM, McCusker RH, Levade T, Moos F, Dantzer R, Kelley KW. The type 1 TNF receptor and its associated adapter protein, FAN, are required for TNFalpha-induced sickness behavior. Psychopharmacology (Berl). 2009 Jan; 201(4):549-56.View in: PubMed

Huey KA, McCusker RH, Kelley KW. Exaggerated expression of skeletal muscle-derived interleukin-6, but not TNFalpha, in mice lacking interleukin-10. J Neuroimmunol. 2008 Aug 13; 199(1-2):56-62. View in: PubMed

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