Focuses on investigating the molecular underpinnings of stress-related mental disorders, with a particular emphasis on post-traumatic stress disorder
Work in the Uddin research group focuses on investigating the molecular underpinnings of stress-related mental disorders, with a particular emphasis on post-traumatic stress disorder (PTSD). We seek to identify genetic, epigenetic, and other biologic signatures associated with risk for, and resilience to, mental illness using samples drawn from both clinical and community-based settings, with the ultimate goal helping to inform interventions that will reduce the burden of mental illness. Our work is inherently interdisciplinary, drawing on tools from diverse fields such as genetics and genomics, psychology, psychiatry, and epidemiology, among others.
Major areas of current research include: characterizing genomic phenotypes of mental illness; delineating the epigenetic changes induced by traumatic stress; identifying gene- and epigene-environment interactions in psychiatric disorders; elucidating the underlying molecular etiology that links mental and physical disorders; and investigating molecular contributions to mental illness that may vary across development.
Uddin, Monica, Angela Bustamante, and Satoshi Toyokawa. "Epigenetic epidemiology of psychiatric disorders." Epigenetics in Psychiatry. Ed. D Avramopoulos, D R. Grayson, and J Peedicayil. Waltham: Elsevier, 2014. 101-127.
Uddin, Monica, and Levent Sipahi. "Epigenetic influences on mental illness over the life course." Life Course Epidemiology of Mental Disorders. Ed. Karestan Koenen, Sasha Rudenstine, Ezra Susser, and Sandro Galea. New York: Oxford University Press, 2013. 238-248.
Uddin, Monica, Ananda Amstadter, Nicole Nugent, and Karestan Koenen. "Genetics and genomics of post-traumatic stress disorder." Handbook of Traumatic Stress Disorders. Ed. J G. Beck and D Sloan. New York: Oxford University Press, 2012. 143-158.
Sipahi, Levent, Derek Wildman, Allison Aiello, Karestan Koenen, Sandro Galea, Asad Abbas, and Monica Uddin. "Longitudinal epigenetic variation of DNA methyltransferase genes is associated with vulnerability to post-traumatic stress disorder." Psychological Medicine epub ahead of print (2014):
Nevell, Lisa, Kezhong Zhang, Allison Aiello, Karestan Koenen, Sandro Galea, Richelo Soliven, Derek Wildman, and Monica Uddin. "Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study" Psychoneuroendocrinology 43 (2014): 62-70.
Diwadkar, Vaibhav, Angela Bustamante, Harinder Rai, and Monica Uddin. "Epigenetics, stress, and their potential impact on brain network function: a focus on the schizophrenia diathesis." Frontiers in Psychiatry 5.71 (2014): doi: 10.3389/fpsyt.2014.00071.
Walsh, Kate, Monica Uddin, Derek Wildman, and Bekh Bradley. "Associations between the SS variant of 5-HTTLPR and PTSD among adults with histories of childhood emotional abuse: results from two African-American independent samples." Journal of Affective Disorders 161 (2014): 91-96.
Uddin, Monica, Levent Sipahi, Jia Li, and Karestan Koenen. "Sex differences in DNA methylation may contribute to risk of PTSD and depression: a review of the evidence." Depression and Anxiety 30 (2013): 1151-1160.
Keyes, Katherine, Kate McLaughlin, Ryan Demmer, Magdalena Cerda, Karestan Koenen, Uddin Monica, and Sandro Galea. "Potentially traumatic events and the risk of six physical health conditions in a population-based sample." Depression and Anxiety 30 (2013): 451-460.
Uddin, Monica, Shun-Chiao Chang, Chao Zhang, Kerry Ressler, Sandro Galea, Katherine Keyes, Kate McLaughlin, Derek Wildman, Allison Aiello, and Karestan Koenen. "ADCYAP1R1 genotype, posttraumatic stress disorder and depression among women exposed to childhood maltreatment." Depression and Anxiety 30 (2013): 251-258.
Johns, Lauren, Allison Aiello, Caroline Cheng, Sandro Galea, Karestan Koenen, and Monica Uddin. "Neighborhood social cohesion and posttraumatic stress disorder in a community-based sample: findings from the Detroit Neighborhood Health Study." Social Psychiatry and Psychiatric Epidemiology 47 (2012): 1899-1906.