Energy Metabolism and Feeding Behavior
Every day we are eating a variety of foods and our body needs to be able to assess what we are eating. Our body senses the quantity and quality of our food in order to get us to stop eating and to be able to direct the nutrients to the appropriate target tissues and metabolic pathways. Thus, differences in how we sense foods may profoundly affect our overall physiology and behavior. Obese and lean humans and other animals are known to respond differently to the same nutrients whether they are delivered directly into the gastrointestinal tract or eaten orally, as measured by changes in food intake, body weight and blood hormone levels. These differences may be accounted for by differences in intestinal morphology and function. The small intestine of obese humans and other animals is longer, has increased villi length/number and increased permeability compared with lean individuals. The mechanism underlying these differences is not known, but may be mediated by a direct action of nutrients on intestinal cells or secondary to the physiological alterations caused by obesity. Our lab is trying to delineate the contribution of diet and obesity by feeding laboratory rats different diets, inducing obesity through the use of these diets, and measuring changes in the morphology and function of the intestine. Results from these studies will not only help us to understand nutrient sensing in obese and lean individuals, but will give us a broader understanding of the mechanisms responsible for nutrient-driven cellular adaption in the intestine and in finding a therapy for intestinal disorders that include Crohn’s disease, irritable bowel syndrome and cancer.
Dailey MJ and Moran TH. 2013. Glucagon-like peptide and appetite. Trends in Endocrinology and Metabolism 24(2): 85-91.
Dailey MJ and Kim S. 2012. Inositol polyphosphate multikinase: an emerging player for the central action of AMP-activated protein kinase. Biochem Biophys Res Commun 421(1):1-3.
Bang S, Kim S, Dailey MJ, Chen Y, Moran TH, Snyder SH, Kim SF. 2012. AMP-activated protein kinase is physiologically regulated by inositol polyphosphate multikinase. Proc Natl Acad Sci USA 109(2): 616-20.
Dailey MJ, Stingl KC and Moran TH. 2012. Dissassociation between preprandial gut peptide release and food anticipatory activity. Endocrinology 153(1):132-42.
Dailey MJ, Moghadam AA and Moran TH. 2011. Jejunal linoleic acid infusions require GLP-1 receptor signaling to inhibit food intake: implications for the effectiveness of Roux-en Y gastric bypass. American Journal of Physiology 301(6): E1184-90.
Bartness TH, Keen-Rhinehart E, Dailey MJ and Teubner BJ. 2011. Neural and hormonal control of food hoarding. American Journal of Physiology 301(3):R641-55.
Moran TH. and Dailey MJ. 2011. Intestinal feedback signaling and satiety. Physiology & Behavior 105(1): 77-81.
Chakraborty A., Koldobskiy, MA, Saleh M, Juluri KR, Snowman AM, Maag D, Huang AS, Potter JJ, Mezey E, Moran TH, Dailey MJ and Solomon SH. 2010 Inositol pyrophosphates mediate obesity and insulin resistance by physiologically inhibiting Akt signaling. Cell 143 (6): 897-910.
Keen-Rhinehart E., Dailey MJ and Bartness TJ. 2010. Physiological mechanisms for food hoarding motivation in animals. Phil. Trans. R. Soc. B 365: 961-975.
Dailey MJ, Tamashiro KLK and Moran TH. 2010. The effect of intrajejunal infusion of specific nutrients on food intake, body mass and peptide levels. Obesity 18: 904-910.