Impacts of early-life nutrition on brain development
As part of my research in the Piglet Nutrition and Cognition Laboratory (PNCL), I use the piglet as a pre-clinical model to assess the impact of early-life nutrition on brain development. My work focuses on the addition of novel compounds to infant formulas in order to determine how these compounds might impact structural and cognitive development. My current MRI work seeks to expand upon our current MRI techniques by developing sequences for contrast-based brain blood volume measures as well as MRI techniques to assess indicators of myelination. Additionally, I am working on development of eyeblink conditioning, a novel associative learning paradigm for the piglet model. This behavioral assessment has proven sensitive to nutritional intervention in other animal models and due to its translational nature will prove useful in pre-clinical infant nutrition studies that utilize the piglet model. Specific areas of infant nutrition in which I am interested include: perinatal choline deficiency, fatty acid metabolism, and prebiotic mediated gut-brain axis maturation.
1. Mudd, A.T, J.E. Fil, L.C. Knight, and R.N. Dilger. Dietary iron repletion following early-life dietary iron deficiency does not correct regional volumetric or diffusion tensor changes in the developing pig brain. Frontiers in Neurology. 2017.
2. Mudd, A.T., S.A. Fleming, B. Labhart, M. Chiclowski, B.M. Berg, S.M. Donovan, and R.N. Dilger. Dietary sialyllactose influences sialic acid concentrations in the prefrontal cortex and magnetic resonance imaging measures in corpus callosum of young pigs. Nutrients. 2017;9:12/12197.
3. Mudd, A.T., K. Berding, M. Wang, S.M. Donovan, and R.N. Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus & brain N-acetylaspartate in the young pig. Gut Microbes. 2017;8:589-600.
4. Mudd, A.T., L.S. Alexander, R.V. Waworuntu, B.M. Berg, S.M. Donovan, and R.N. Dilger. What’s in milk? How nutrition influences the developing brain. Frontiers for Young Minds. 2017;5:16.
5. Mudd, A.T. and R.N. Dilger. Early-life nutrition and neurodevelopment: use of the piglet as a translational model. Advances in Nutrition. 2017;8:92-104.
6. Mudd, A.T., L.S. Alexander, S.K. Johnson, C.M. Getty, O.V. Malysheva, M.A. Caudill, and R.N. Dilger. Perinatal dietary choline deficiency in sows influences concentrations of choline metabolites, fatty acids, and amino acids in milk throughout lactation. Journal of Nutrition. 2016;146:2216-2223.
7. Mudd, A.T.*, J. Salcedo*, L.S. Alexander, S.K. Johnson, C.M. Getty, M. Chichlowski, B.M. Berg, D. Barile, and R.N. Dilger. Porcine milk oligosaccharides and sialic acid concentrations vary throughout lactation. Frontiers in Nutrition. 2016;3:39.
8. Jacob, R. M., A. T. Mudd, L. S. Alexander, C. S. Lai, and R. N. Dilger. Comparison of brain development in sow-reared and artificially reared piglets. Front. Pediatr. 2016;4:95.
9. Leyshon, B.J., E.C. Radlowski, A.T. Mudd, A.J. Steelman, and R.W. Johnson. Postnatal iron deficiency alters brain development in piglets. Journal of Nutrition. 2016;146:1420-1427.
10. Mudd, A.T., R.V. Waworuntu, B.M. Berg, and R.N. Dilger. Dietary alpha-lipoic acid alters piglet neurodevelopment. Frontiers in Pediatrics. 2016;4:44.
11. Berding, K., M. Wang, M.H. Monaco, L.S. Alexander, A.T. Mudd, M. Chichlowski, R.V. Waworuntu, B.M. Berg, M.J. Miller, R.N. Dilger, and S.M. Donovan. Prebiotics and bioactive milk fractions affect gut development, microbiota, and neurotransmitter expression in piglets. Journal of Pediatric Gastroenterology and Nutrition. 2016;63:688-697.
12. Mudd, A.T., L.S. Alexander, K. Berding, R.V. Waworuntu, B.M. Berg, S.M. Donovan, and R.N. Dilger. Dietary prebiotics, milk fat globule membrane and lactoferrin affects structural neurodevelopment in the young piglet. Frontiers in Pediatrics. 2016;4:4.
13. Mudd, A.T., C.M. Getty, B.P. Sutton, and R.N. Dilger. Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. Nutritional Neuroscience. 2016;19:425-433.