Austin Mudd

amudd2@illinois.edu

1207 W Gregory Dr
ASL 190
Urbana, IL 61801

Lab Page
Curriculum Vita
Publications

Austin Mudd

NSO President 2015-2016

Impacts of early-life nutrition on brain development

As part of my research in the Piglet Nutrition and Cognition Laboratory (PNCL), I use the piglet as a pre-clinical model to assess the impact of early-life nutrition on brain development. My work focuses on the addition of novel compounds to infant formulas in order to determine how these compounds might impact structural and cognitive development. My current MRI work seeks to expand upon our current MRI techniques by developing sequences for contrast-based brain blood volume measures as well as MRI techniques to assess indicators of myelination. Additionally, I am working on development of eyeblink conditioning, a novel associative learning paradigm for the piglet model. This behavioral assessment has proven sensitive to nutritional intervention in other animal models and due to its translational nature will prove useful in pre-clinical infant nutrition studies that utilize the piglet model. Specific areas of infant nutrition in which I am interested include: perinatal choline deficiency, fatty acid metabolism, and prebiotic mediated gut-brain axis maturation.

Research Areas

Representative Publications

1. Mudd, A.T., S.A. Fleming, B. Labhart, M. Chichlowski, B. M. Berg, S. M. Donovan, and R. N. Dilger. Dietary sialyllactose influences sialic acid concentrations in the prefrontal cortex and magnetic resonance imaging measures in corpus callosum of young pigs. Nutrients. 2017;9:1297.

2. Mudd, A.T., K. Berding, M. Wang, S.M. Donovan, and R.N. Dilger. Serum cortisol mediates the relationship between fecal Ruminococcus & brain N-acetylaspartate in the young pig. Gut Microbes. 2017.

3. Mudd, A. T., L. S. Alexander, R. V. Waworuntu, B. M. Berg, S. M. Donovan, and R. N. Dilger. What’s in milk? How nutrition influences the developing brain. Front. Young Minds. 2017;5:16.

4. Mudd, A. T. and R. N. Dilger. Early-life nutrition and neurodevelopment: use of the piglet as a translational model. Adv. Nutr. 2017;8:92-104.

5. Mudd, A. T., L. S. Alexander, S. K. Johnson, C. M. Getty, O. V. Malysheva, M. A. Caudill, and R. N. Dilger. Perinatal dietary choline deficiency in sows influences concentrations of choline metabolites, fatty acids, and amino acids in milk throughout lactation. J. Nutr. 2016;146:2216-2223. 6. Mudd, A.T.*, J. Salcedo*, L. S. Alexander, S. K. Johnson, C. M. Getty, M. Chichlowski, B. M. Berg, D. Barile, and R. N. Dilger. Porcine milk oligosaccharides and sialic acid concentrations vary throughout lactation. Front. Nutr. 2016;3:39.

7. Jacob, R. M., A. T. Mudd, L. S. Alexander, C. S. Lai, and R. N. Dilger. Comparison of brain development in sow-reared and artificially reared piglets. Front. Pediatr. 2016;4:95.

8. Leyshon, B. J., E. C. Radlowski, A. T. Mudd, A. J. Steelman, and R. W. Johnson. Postnatal iron deficiency alters brain development in piglets. J. Nutr. 2016;146:1420-1427.

9. Mudd, A. T., R. V. Waworuntu, B. M. Berg, and R. N. Dilger. Dietary alpha-lipoic acid alters piglet neurodevelopment. Front. Pediatr. 2016;4:44.

10. Berding, K., M. Wang, M. H. Monaco, L. S. Alexander, A. T. Mudd, M. Chichlowski, R. V. Waworuntu, B. M. Berg, M. J. Miller, R. N. Dilger, and S. M. Donovan. Prebiotics and bioactive milk fractions affect gut development, microbiota, and neurotransmitter expression in piglets. J. Pediatr. Gastroenterol. Nutr. 2016;63:688-697.

11. Mudd, A.T., L.S. Alexander, K. Berding, R. V. Waworuntu, B. M. Berg, S. M. Donovan, and R. N. Dilger. Dietary prebiotics, milk fat globule membrane and lactoferrin affects structural neurodevelopment in the young piglet. Front. Pediatr. 2016;4:4.

12. Mudd, A.T., C. M. Getty, B. P. Sutton, and R. N. Dilger. Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. Nutri. Neuro. 2016;19:425-433.

Complete Publications List (PubMed)

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