Department of Molecular and Integrative Physiology, 524 Burrill Hall 407 South Goodwin Avenue, Urbana, IL
Office: (217) 244-6839
Lab: (217) 979-2111
Fax: (217) 333-1133
Epilepsy is a common brain disorder characterized by seizures, which are abnormally excessive and synchronous discharges of neuronal activity. Temporal lobe epilepsy (TLE) is the most common risk of hippocampal sclerosis and memory deficits. Yet, the cause and pathogenesis of TLE is poorly understood.
As one of activity-dependent plasticity considered as the main causing factor in acquired epilepsy,Homeostatic plasticity is engaged when neurons need to stabilize their synaptic strength and intrinsic excitability within a physiological range in response to prolonged destabilizing changes in neuronal activity. For instance, the infusion of TTX, a sodium channel blocker in hippocampus for 2-4 week gives a rise to TLE, indicating that homeostatic synaptic plasticity may mediate the pathogenesis of epilepsy.
The goal of my research in Dr. Chung's lab is to dissect the molecular mechanisms underlying synaptic scaling in hippocampal neurons and investigate the link between synaptic scaling and seizure propensity.
* Equal contribution
Shim HG*, Jang SS*, Jang DC, Park JM, Kim SJ. (2018). TNF-? increases the intrinsic excitability of cerebellar Purkinje cells through elevating glutamate release in Bergmann Glia.Sci Rep. 2018 Aug 2;8(1):11589. doi: 10.1038/s41598-018-29786-9
Kim IJ, Lee J, Oh SJ, Yoon MS, Jang SS, Holland RL, Reno ML, Hamad MN, Maeda T, Chung HJ, Chen J, Blanke SR. (2018). Helicobacter pylori Infection Modulates Host Cell Metabolism through VacA-Dependent Inhibition of mTORC1. Cell Host Microbe. 2018 May 9;23(5):583-593.e8. doi: 10.1016/j.chom.2018.04.006.
Jang SS, Jeong HG, Chung HJ. (2017). Electroconvulsive Seizures in Rats and Fractionation of Their Hippocampi to Examine Seizure-induced Changes in Postsynaptic Density Proteins. J Vis Exp. 2017 Aug 15;(126). doi: 10.3791/56016
Jang SS*, Royston SE*, Chung HJ. (2016).Seizure-induced regulations of amyloid-beta, STEP61, STEP61 substrates involved in hippocampal synaptic plasticity. Neural Plast. 2016;2016:2123748. doi: 10.1155/2016/2123748. Epub 2016 Apr 5.PMID: 27127657
Jang SS, Chung HJ. (2016).Emerging Link between Alzheimer’s Disease and Homeostatic Synaptic Plasticity. Neural Plast. 2016;2016:7969272. doi: 10.1155/2016/7969272. Epub 2016 Feb 25. Review.PMID: 27019755
Shim HG, Jang SS, Jang DC, Park JM, Kim SJ. (2016). mGlu1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells. J Neurophysiol. 2016 Feb 24:jn.00566.2015. doi: 10.1152/jn.00566.2015.PMID: 26912592
Jang SS*, Royston SE*, Xu J, Cavaretta JP, Vest MO, Lee KY, Lee S, Jeong HG, Lombroso PJ, Chung HJ. (2015). Regulation of STEP61 and tyrosine-phosphorylation of NMDA and AMPA receptors during homeostatic synaptic plasticity. Mol Brain. 2015 Sep 22;8(1):55. doi: 10.1186/s13041-015-0148-4.
Jang SS, Choi JH, Im DS, Park S, Park JS, Park SM, Joe EH, Jou I, Suh YH. (2014). The phosphorylation of STAT6 during ischemic reperfusion in rat cerebral cortex. Neuroreport. Jan 8;25(1):18-22
Jang SS, Park J, Hur SW, Hong YH, Hur J, Chae JH, Kim SK, Kim J, Kim HS, Kim SJ. (2011). Endothelial Progenitor Cells functionally Express Inward Rectifier Potassium Channels. Am J physiol Cell Physiol. Jul;301(1):C150-61
Shin HY*, Hong YH*, Jang SS, Chae HG, Paek SL, Moon HE, Kim DG, Kim J, Paek SH, Kim SJ. (2010). A role of Canonical Transient Receptor Potential 5 Channel in Neuronal Differentiation from A2B5 Neuronal Progenitor Cells. PLoS One. May 7;5(5):
Hong YH, Kim JY, Lee JH, Chae HG, Jang SS, Jeon JH, Kim CH, Kim J, Kim SJ. (2009). Agonist-induced internalization of mGluR1alpha is mediated by caveolin. J Neurochem. Oct;111(1):61-71