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Newmark, Phillip A.
Associate Professor, Cell and Developmental Biology
B.A., Boston University
Ph.D. University of Colorado at Boulder
Research Areas
Regeneration in planarians
My laboratory is interested in understanding the molecular mechanisms that allow some organisms to regenerate missing structures. We use the freshwater planarian as a model to study how stem cells are maintained in intact animals and how they are regu-lated in response to injury. We are also interested in understanding the signals that guide the stem cells to adopt neuronal fates and how these newly born neurons rebuild the central nervous system.
Representative Publications
Cebrià,, F., Guo, T., Jopek, J., and P. A. Newmark. 2007. Regulation of midline regeneration and maintenance by a planarian slit orthologue. Developmental Biology, 307:394-406 (cover).
Wang, Y., Zayas, R.M., Guo, T., and P. A. Newmark. 2007. nanos function is essential for development and regeneration of planarian germ cells. Proc. Natl Acad. Sci. USA 104:5901-5906.
Cebrià,, F. and P. A. Newmark. 2007. Morphogenesis defects are associated with abnormal nervous system regeneration following roboA RNAi in planarians. Development 134: 833-837.
Guo, T., Peters, A.H.F.M., and P.A. Newmark. 2006. A bruno-like gene is required for stem cell maintenance in planarians. Developmental Cell 11: 159-169 (cover).
Zayas, R.M., Hernández, A, Habermann, B., Wang, Y., Stary, J.M., and P. A. Newmark. 2005. The planarian Schmidtea mediterranea as a model for epigenetic germ cell specification: analysis of ESTs from the hermaphroditic strain. Proc. Natl. Acad. Sci. 102:18491-18496.
Additional Information
Collaborative Projects:
Related Research (By Area):
Bioinformatics and Neuroinformatics
Cell Signaling and Communication
Development
Neurogenomics and Sociogenomics
Contact information:
