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Stubbs, Lisa
Professor, Cell and Developmental Biology
[Department website]
Ph.D., University of California, San Diego (Biology)
Research Areas
Evolution of genome structure and regulatory networks; Mouse models for human disease
I was dually trained in mouse genetics and genomics and have an abiding interest in both fields. My group combines genetics and genomic approaches to explore the functional content of the vertebrate genome, focusing especially on the evolution of cis- and trans-acting components of vertebrate regulatory machinery. Our interests include aspects of regulatory biology that are deeply conserved but we are particularly interested in those components that have changed over evolutionary time. Working against a background of deep conservation, these changing components hold potential to explain biological differences between species, but also between different individuals in the same populations.
Representative Publications
Elso C, Lu X, Morrison S, Tarver A, Thompson H, Thurkow H, Yamada NA, and Stubbs L. 2008. Germline translocations in mice: unique tools for analyzing gene function and long-distance regulatory mechanisms. J National Cancer Inst, in press.
Hamilton AT, Huntley S, Tran-Gyamfi M, Baggott DM, Gordon L, and Stubbs L. 2006. Evolutionary expansion and divergence in the ZNF91 subfamily of primate-specific zinc finger genes. Genome Research 16:584-594.
Huntley S, Baggott DM, Hamilton AT, Tran-Gyamfi M, Yang S, Kim J, Gordon L, Branscomb E, and Stubbs L. 2006. A comprehensive catalog of human KRAB-associated zinc finger genes: insights into the evolutionary history of a large family of transcriptional repressors. Genome Research 16:669-677.
Ovcharenko I, Loots GG, Nobrega MA, Hardison RC, Miller W and Stubbs L. 2005. Odor specific effects on re-entrainment following phase advances in the diurnal rodent Octodon degus. Genome Research 15:137-145.
Ovcharenko I, Loots GG, Giardine BM, Hou M, Ma J, Hardison RC, Stubbs L, and Mulan MW. 2005. Multiple-sequence local alignment and visualization for studying function and evolution. Genome Research 15:184-194.
Kim J, Bergmann A, Lucas S, Stone R, and Stubbs L. (004. Lineage-specific imprinting and evolution of the zinc finger gene ZIM2. Genomics 84:47-58.
Elso CE, Lu X, Culiat CT, Rutledge J, Cacheiro NLA, Generoso WM, and Stubbs LJ. 2004. Heightened susceptibility to gastric infection, chronic gastritis, and metaplasia in Kcnq1 mutant mice. Hum Mol Genet 13:2813-2821.
Additional Information
Related Research (By Area):
Neurological and Psychiatric Conditions
Neurogenomics and Sociogenomics
Contact information:
