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Gulley, Joshua M.
Assistant Professor, Psychology
Ph.D., Indiana University
Research Areas
Neurobiology of drug and alcohol addiction
Dr. Gulley's laboratory focuses on the neurobiology of drug and alcohol addiction, with an emphasis on behavioral and physiological analyses of brain reward pathways in animal models of drug taking and chronic drug exposure. Two main questions are currently being addressed: (1) What are the neurobiological mechanisms that underlie individual differences in the behavioral response to drugs of abuse? (2) How does a long history of drug taking contribute to continued substance abuse and/or facilitate relapse after a period of abstinence?
To address these research questions, Dr. Gulley‘s laboratory uses behavioral and physiological methods of analysis, both alone and in combination. For behavior, they study drug responses using operant self-administration, conditioned place preference, and behavioral sensitization techniques. Their primary physiological measure is multiple neuron electrophysiology, which allows one to record the activity of a large number of brain cells as animals are actively behaving.
Representative Publications
Hall DA, Stanis JJ, Avila HM, Gulley JM (2008). A comparison of amphetamine- and methamphetamine-induced locomotor activity in rats: evidence for qualitative differences in behavior. Psychopharmacology, 195:469-78. Epub 2007 Sep 17.
Stanis JJ, Marquez Avila H, White MD, Gulley JM (2008). Dissociation between long-lasting behavioral sensitization to amphetamine and impulsive choice in rats performing a delay-discounting task. Psychopharmacology, 199:539-548. Epub 2008 May 13.
Stanis JJ, Burns RM, Sherrill LK, Gulley JM (2008). Disparate cocaine-induced locomotion as a predictor of choice behavior in rats trained in a delay-discounting task. Drug and Alcohol Dependence. 98:54-62. Epub 2008 June 6.
Gulley JM (2007). Individual differences in novelty- and cocaine-induced locomotor activity as predictors of food-reinforced operant behavior in two outbred rat strains. Pharmacology, Biochemistry and Behavior, 86:749-57. Epub 2007 Mar 12.
Hanania T, Gulley JM, Salaz DO, Larson GA, Zahniser NR. 2004. Role of the dopamine transporter in the differential cocaine-induced locomotor activation of inbred long-sleep and short-sleep mice. Neuropsychopharmacology 29(10):1814-1822.
Briegleb SK, Gulley JM, Hoover BR, Zahniser NR. 2004. Individual differences in cocaine- and amphetamine-induced activation of male Sprague-Dawley rats: Contribution of the dopamine transporter. Neuropsychopharmacology 29(12):2168-2179.
Gulley JM, Reed JL, Kuwajima M, Rebec GV. 2004. Amphetamine-induced behavioral activation is associated with variable changes in basal ganglia output neurons in awake, behaving rats. Brain Research 1012:108-118.
Gulley JM, Zahniser NR. 2003. Rapid regulation of dopamine transporter function by substrates, blockers and presynaptic receptor ligands. European Journal of Pharmacology 479:139-152.
Gulley JM, Hoover BR, Larson GA, Zahniser NR. 2003. Individual differences in cocaine-induced locomotor activity in rats: behavioral characteristics, cocaine pharmacokinetics and the dopamine transporter. Neuropsychopharmacology 28:2089-2101.
Additional Information
Related Research (By Area):
Cell Signaling and Communication
Learning, Memory, and Plasticity
Neurological and Psychiatric Conditions
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