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Hing, Huey
Assistant Professor, Cell and Developmental Biology
B.S., National University of Singapore
Ph.D., Yale University
Research Areas
Axon guidance: Development of the visual and olfactory systems, growth cone, signal transduction, actin cytoskeleton
During development neurons extend their axons with great precision over long distances to reach target cells. This feat of navigation is performed by a motile structure at the tip of the axon, the growth cone. Receptors on the surface of the growth cone detect guidance cues in the environment and signal to the actin cytoskeleton resulting in changes in its direction of migration. Recent years have witnessed tremendous progress in identifying guidance cues and their receptors. However, mechanisms that transmit signals from the receptor to the actin cytoskeleton remain largely unknown. Research efforts in our lab are aimed at elucidating these signaling mechanisms that convert receptor-ligand interactions into changes in cytoskeletal structure and motility.
Representative Publications
Ang LH, Chen WT, Yao Y, Ozawa R, Tao E, Yonekura J, Uemura T, Keshishian H and Hing H. (2006) Lim Kinase Regulates the Development of Olfactory and Neuromuscular Synapses. Dev Biol.
Zhang DS, Zhou WG, Yin C, Chen WT, Ozawa R, Ang L H, Anandan L, Aigaki T and Hing H. (2006). A Misexpression Screen for Genes altering the Olfactory Map in Drosophila. Genesis 44: 189-201.
Ang LH, Kim J, Stepensky V and Hing H. 2003. Dock and Pak regulate olfactory axon pathfinding in Drosophila. Development 130:1307-1316.
Hing H, Xiao J, Harden N, Lim L, Zipursky SL. 1999. Pak functions downstream of Dock to regulate photoreceptor axon guidance in Drosophila. Cell 97(7):853-63.
Additional Information
Collaborative Projects:
My lab continues to collaborate with the laboratories of Professors Akira Chiba and Tzumin Lee, both located on the same floor, on a vareity of technological (genetic and molecular) issues in order for us to stay at the cutting edge of the Drosophila research.
Related Research (By Area):
