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Roy, Edward J.
Professor, Molecular and Integrative Physiology
B.A., Brown University
Ph.D., University of Massachusetts
Research Areas
Brain tumors
Brain tumors are generally resistant to conventional cancer therapies. In order to develop new treatments, we are using transgenic mice that develop tumors of the choroid plexus, modeling certain types of human pediatric brain tumors. We have developed bispecific antibodies that link surface markers on the tumor to cytotoxic T cells, allowing the immune cells to kill the tumor cells. We are developing ways to enhance this strategy and testing it in vivo.
Representative Publications
Roy, E.J., Takikawa, O., Kranz, D.M., Brown, A.R., and Thomas, D.L. 2005. Neuronal localization of indoleamine 2,3-dioxygenase in mice. Neuroscience Letters, 387(2):95–9.
Gawlick, U., Kranz, D.M., Schepkin, V.D., and Roy, E.J. 2004. A conjugate of a tumor-targeting ligand and a T cell costimulatory antibody to treat brain tumors. Bioconjugate Chemistry, 15(5):1137–45.
Roy, E.J., Gawlick, U. Orr, B.A., and Kranz, D.M.. 2004. Folate-mediated targeting of T Cells to tumors. Advanced Drug Delivery Reviews, 56(8):1219–31.
Roy, E.J., Kim, M., Soto, C.M., and Thomas, D.L. August 2006. Does stroma play a role in T cell mediated rejection of brain tumors? Aspen Symposium on Brain Tumor Immunotherapy
Odintsov, B., Atasarkin, V., Gorbenko, O., Kaul, A., and Roy, E.J. Adjustable Curie-temperature nanoparticles for imaging and highly controllable hyperthermia cancer therapy. International Conference on Composites or Nano Engineering, July 2006.
Thomas, D.L., Brown, A.R., and Roy, E.J. Immunostimulatory CpG DNA increases brain tumor infiltrating T cells. Society for Neuroscience, November 2005.
Additional Information
Related Research (By Area):
Neurological and Psychiatric Conditions
Contact information:
