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Ferguson, Duncan
Department Head, Veterinary Biosciences
V.M.D., University of Pennsylvania
Ph.D., University of Pennsylvania (Pharmacology)
Research Areas
Thyroid hormone physiology, pharmacology and toxicology; mechanisms of action of environmental thyroid hormone disrupting compounds on neurodevelopment; etiopathogenesis of hyperthyroidism in the cat; use of molecular genetic techniques for improvement of thyroid diagnostic tests in domestic animals; mechanisms of obesity, insulin resistance, and Type II diabetes mellitus in the cat model; veterinary clinical pharmacology.
Representative Publications
Hoenig, M., Z. Caffall, and D.C. Ferguson. (2008) Triiodothyronine differentially regulates key metabolic factors in lean and obese cats. Domest. Anim. Endocrinol. 34:229-237.
Kley, S., Z. Caffall, E. Tittle, D.C. Ferguson, and M. Hoenig. (2008) Development of a feline proinsulin immunoradiometric assay and a feline proinsulin enzyme-linked immunosorbent assay (ELISA): A novel application to examine beta cell function in cats. Domest. Anim. Endocrinol. 34:311-318.
Ferguson, D.C., Z. Caffall, and H. Hoenig. (2007) Obesity increases free thyroxine proportionally to nonesterified fatty acid concentrations in adult neutered female cats. J. Endocrinol. 194:267-273
Hoenig M, Thomaseth K, Waldron M, and Ferguson DC. 2007. Fatty acid turnover, substrate oxidation, and heat production in lean and obese cats during the euglycemic hyperinsulinemic clamp. Domestic Animal Endocrinology 32(4):329-338.
Hoenig M, Thomaseth K, Waldron M, Brandao J, and Ferguson DC. 2006. Assessment and mathematical modeling and insulin sensitivity in lean and obese cats. Domestic Animal Endocrinology 31(4):373-389.
Fisher JW, Campbell J, Muralidhara S, Bruckner JV, Ferguson DC, Mumtaz M, H El-Masri H, Harmon B, Hedge J, Crofton K, and Almekinder TL. 2006. Effect of PCB 126 on hepatic metabolism of thyroxine and pertubations in the hypothalamic- pituitary-thyroid axis in the rat. Toxicological Sciences 90(1):87-95.
Rayalam S, Eizenstat LD, Davis RR, Hoenig M, and Ferguson DC. 2006. Expression and purification of feline thyrotropin (fTSH): immunological detection and bioactivity of heterodimeric and yoked glycoproteins. Domestic Animal Endocrinology 30:185-202.
Rayalam S, Eizenstat LD, Hoenig M, and Ferguson DC. 2006. Cloning and sequencing of feline thyrotropin (fTSH): heterodimeric and yoked constructs. Domestic Animal Endocrinology 30:203-217.
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