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Beverly, J. Lee
Associate Professor, Animal Sciences, Nutritional Sciences
B.S., University of Florida
M.S., Virginia Tech
Ph.D., University of Georgia
Research Areas
Central regulation of energy balance and nutrient homeostasis
My laboratory is involved in identifying those mechanisms in the brain that: (1) monitor and maintain circulating nutrient concentrations, (2) are involved in maintaining energy balance, and (3) are acutely responsive to dietary amino acids. We have identified underlying neurochemical mechanisms in the hypothalamus involved in glucose homeostasis (and possibly other calorigenic molecules). These glucoregulatory mechanisms appear to be affected by chronic alterations in energy balance, such as obesity, and in diabetes. We have recently begun to study the impact of dietary manipulation of plasma amino acid profile on behavior. Short-term memory tasks may be affected by neurochemical changes in the hippocampus sensitive to changes in plasma amino acid profile.
Representative Publications
Barnes, M.B. and J.L. Beverly. (2007) Nitric oxide's role in glucose homeostasis. Am. J. Physiol. 293:R590-R591.
Chan, O., M. Lawson, W. Zhu, J.L. Beverly, and R.S. Sherwin. (2007) ATP-sensitive potassium channels regulate the release of GABA in the ventromedial hypothalamus during hypoglycemia. Diabetes 56:1120-1126.
Doane, D.F., M.A. Lawson, J.R. Meade, C.M. Kotz, and J.L. Beverly. (2007) Orexin-induced feeding requires NMDA receptor activation in the perifornical region of the lateral hypothalamus. Am. J. Physiol. 293:R1022-R1026.
Buff, C.E., N.F. Shay, and J.L. Beverly. (2006) Noradrenergic activity in the paraventricular nucleus and macronutrient choice during early dark onset by zinc deficient rats. Nutritional Neuroscience 9:189-193.
Fugo, K.R., M.A. Lawson, and J.L. Beverly. (2006) Ibotenic acid lesions reduce noradrenergic activation in ventromedial hypothalamus during hypoglycemia. Brain Res. 1111:105-110.
de Vries MG, Lawson MA, and Beverly JL. 2005. Hypoglycemia-induced noradrenergic activation in the VMH is a result of decreased ambient glucose. Am. J. Physiol. 289:R977-R981.
de Vries MG, and Beverly JL. 2004. Dissociation of hypothalamic noradrenergic activity and sympatho-adrenal responses to recurrent hypoglycemia. Am. J. Physiol. 286:R910-915.
de Vries MG, Arseneau LM, and Beverly JL. 2003. Changes in extracellular glucose in rat ventromedial hypothalamus to acute and recurrent hypoglycemia determined with in vivo microdialysis. Diabetes. 52(11):2767-73.
Cole AC, Shay NF, O'Brien S, and Beverly JL. 2002. Zinc deficient rats are insensitive to glucoprivation caused by 2-deoxy-D-glucose. Nutr. Neurosci. 5(1):59-64.
Huntington CE, Shay NF, Arseneau LM, and Beverly JL. 2002. Zinc status affects neurotransmitter activity in the paraventricular nucleus of rats. J. Nutr. 132:270-275.
Additional Information
Related Research (By Area):
Cell Signaling and Communication
Neurological and Psychiatric Conditions
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