Rapid and reversible dendritic arborization in C. elegans sensory neurons
Environmental factors have significant and immediate neuronal effects. In the nematode Caenorhabditis elegans, six sensory neurons arborize extensively in response to low food, high population density, and a warm environment. When returned to a favorable environment, the dendrites largely resorb their branches. Dendritic arborization and resorption is not limited to C. elegans and has been observed in hibernating rodents and humans, demonstrating that this is a highly conserved cellular response to stress. Using C. elegans as a model, we can observe this dynamic process in vivo and begin to understand the underlying molecular pathways.
Androwski, R.J., Flatt, K.M. and Schroeder, N.E., 2017. Phenotypic plasticity and remodeling in the stress?induced Caenorhabditis elegans dauer. Wiley Interdisciplinary Reviews: Developmental Biology.
Juan Wang, Rachel Kaletsky, Malan Silva, April Williams, Leonard A. Haas, Rebecca J. Androwski, Jessica N. Landis, Cory Patrick, Alina Rashid, Dianaliz Santiago-Martinez, Maria Gravato-Nobre, Jonathan Hodgkin, David H. Hall, Coleen T. Murphy, Maureen M. Barr. 2015. Cell-Specific Transcriptional Profiling of Ciliated Sensory Neurons Reveals Regulators of Behavior and Extracellular Vesicle Biogenesis. Current Biology. 25(24):3232-38.
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