Austin Mudd

1207 W Gregory Dr
ASL 190
Urbana, IL 61801

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Curriculum Vita

Austin Mudd

NSO President 2015-2016

Impacts of early-life nutrition on brain development

As part of my research in the Piglet Nutrition and Cognition Laboratory (PNCL), I use the piglet as a pre-clinical model to assess the impact of early-life nutrition on brain development. My work focuses on the addition of novel compounds to infant formulas in order to determine how these compounds might impact structural and cognitive development. My current MRI work seeks to expand upon our current MRI techniques by developing sequences for contrast-based brain blood volume measures as well as MRI techniques to assess indicators of myelination. Additionally, I am working on development of eyeblink conditioning, a novel associative learning paradigm for the piglet model. This behavioral assessment has proven sensitive to nutritional intervention in other animal models and due to its translational nature will prove useful in pre-clinical infant nutrition studies that utilize the piglet model. Specific areas of infant nutrition in which I am interested include: perinatal choline deficiency, fatty acid metabolism, and prebiotic mediated gut-brain axis maturation.

Research Areas

Representative Publications

1. Mudd AT, Alexander LS, Johnson SK, Getty CM, Malysheva OV, Caudill MA, Dilger RN. Perinatal dietary choline deficiency in sows influences concentrations of choline metabolites, fatty acids, and amino acids in milk throughout lactation. J of Nutr. doi: 10.3945/jn.116.238832.

2. Mudd AT, Dilger RN. Early-life nutrition and neurodevelopment: use of the piglet as a translational model. Adv. Nutr. 2016. doi: 10.3945/an.116.013243.

3. Mudd AT*, Salcedo J*, Alexander LS, Johnson SK, Getty CM, Chichlowski M, Berg BM, Barile D, Dilger RN. Porcine milk oligosaccharides and sialic acid concentrations vary throughout lactation. Front. Nutr. 2016. 3:39. doi: 10.3389/fnut.2016.00039.

4. Jacob RM, Mudd AT, Alexander LS, Lai CS, Dilger RN. Comparison of brain development in sow-reared and artificially reared piglets. Fron. Pediatr. 2016. 4:95. doi: 10.3389/fped.2016.00095.

5. Leyshon BJ, Radlowski EC, Mudd AT, Steelman AJ, Johnson RW. Postnatal iron deficiency alters brain development in piglets. J Nutr. 2016. doi: 10.3945/jn.115.223636.

6. Mudd AT, Waworuntu RV, Berg BM, Dilger RN. Dietary alpha-lipoic acid alters piglet neurodevelopment. Front. Pediatr. 2016. 4:44. doi: 10.3389/fped.2016.00044.

7. Berding K, Wang M, Monaco MH, Alexander LS, Mudd AT, Chichlowski M, Waworuntu R, Berg B, Miller MJ, Dilger RN, Donovan SM. Prebiotics and bioactive milk fractions affect gut development, microbiota, and neurotransmitter expression in piglets. J of Pediatr Gastroenterol Nutr. 2016. doi: 10.1097/MPG.0000000000001200.

8. Mudd AT, Alexander LS, Berding K, Waworuntu RV, Berg BM, Donovan SM and Dilger RN. Dietary prebiotics, milk fat globule membrane and lactoferrin affects structural neurodevelopment in the young piglet. Front. Pediatr. 2016. 4:4. doi: 10.3389/fped.2016.00004.

9. Mudd AT, Getty CM, Sutton BP, Dilger RN. Perinatal choline deficiency delays brain development and alters metabolite concentrations in the young pig. Nutri Neuro. 2015. doi: 10.1179/1476830515Y.0000000031.

Complete Publications List (PubMed)

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